Synthesis and Characterization of Drug-Loaded Poly(ε-caprolactone)Silica Hybrid Nanofibrous Scaffolds
Joint Authors
Kim, Hyoun-Ee
Shin, Kwan-Ha
Koh, Young-Hag
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We produced drug-loaded poly(ε-caprolactone) (PCL)/silica hybrid nanofibrous scaffolds with various silica sol contents (0 vol%, 10 vol%, 15 vol%, and 20 vol%) using electrospinning and examined their physicochemical properties, mechanical properties, drug release behavior, and in vitro biocompatibility to evaluate their potential application for guided bone regeneration (GBR).
The loading efficiency of tetracycline hydrochloride (TCH) drug was remarkably enhanced by hybridizing the PCL solution with the silica sol.
All produced hybrid scaffolds had a highly nanofibrous structure, in which the silica phase was homogeneously hybridized with the PCL polymer, while preserving their intrinsic characteristics.
This led to considerable increases in hydrophilicity and mechanical properties (e.g., ultimate tensile strength and elastic modulus).
In addition, the release rate and cumulative maximum amounts of the TCH from the hybrid scaffolds significantly increased with increasing the silica content, while all produced hybrid nanofibrous scaffolds showed good biocompatibility assessed by in vitro cell tests.
American Psychological Association (APA)
Shin, Kwan-Ha& Koh, Young-Hag& Kim, Hyoun-Ee. 2013. Synthesis and Characterization of Drug-Loaded Poly(ε-caprolactone)Silica Hybrid Nanofibrous Scaffolds. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1007693
Modern Language Association (MLA)
Shin, Kwan-Ha…[et al.]. Synthesis and Characterization of Drug-Loaded Poly(ε-caprolactone)Silica Hybrid Nanofibrous Scaffolds. Journal of Nanomaterials No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1007693
American Medical Association (AMA)
Shin, Kwan-Ha& Koh, Young-Hag& Kim, Hyoun-Ee. Synthesis and Characterization of Drug-Loaded Poly(ε-caprolactone)Silica Hybrid Nanofibrous Scaffolds. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1007693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1007693