Obtaining of Sol-Gel Ketorolac-Silica Nanoparticles: Characterization and Drug Release Kinetics
Joint Authors
López Goerne, T. M.
López García, M. G.
Rodríguez Grada, G.
Ortiz Pérez, I.
Gómez López, E.
Alvarez Lemus, M. A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among most commonly prescribed medications worldwide.
NSAIDs play an important role due to their pronounced analgesic potency, anti-inflammatory effects, and lesser side effects compared to opioids.
However, adverse effects including gastrointestinal and cardiovascular effects seriously complicate their prolonged use.
In the present work we prepare SiO2-based nanoparticles with ketorolac, for controlled release proposes.
The nanomaterials were prepared by the sol-gel technology at acidic conditions and two different water/alcoxide ratios were used.
FTIR spectroscopy was performed in order to characterize the solids and drug-SiO2 interactions.
Thermal analysis and nitrogen adsorption isotherms showed thermal stability of the drug and confirmed the presence of particles with high surface area.
Transmission electron micrographies of the samples showed the nanosize particles (20 nm) forming aggregates.
Drug release profiles were collected by means of UV-Vis spectroscopy and kinetic analysis was developed.
Release data were fitted and 1 : 8 sample showed a sustained release over ten hours; 90% of the drug was delivered at the end of the time.
American Psychological Association (APA)
López Goerne, T. M.& López García, M. G.& Rodríguez Grada, G.& Ortiz Pérez, I.& Gómez López, E.& Alvarez Lemus, M. A.. 2013. Obtaining of Sol-Gel Ketorolac-Silica Nanoparticles: Characterization and Drug Release Kinetics. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1007783
Modern Language Association (MLA)
López Goerne, T. M.…[et al.]. Obtaining of Sol-Gel Ketorolac-Silica Nanoparticles: Characterization and Drug Release Kinetics. Journal of Nanomaterials No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1007783
American Medical Association (AMA)
López Goerne, T. M.& López García, M. G.& Rodríguez Grada, G.& Ortiz Pérez, I.& Gómez López, E.& Alvarez Lemus, M. A.. Obtaining of Sol-Gel Ketorolac-Silica Nanoparticles: Characterization and Drug Release Kinetics. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1007783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1007783