The Role of TNF-α and TNF Superfamily Members in the Pathogenesis of Calcific Aortic Valvular Disease
Joint Authors
Galeone, Antonella
Paparella, Domenico
Colucci, Silvia
Brunetti, Giacomina
Grano, Maria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Calcific aortic valve disease (CAVD) represents a slowly progressive pathologic process associated with major morbidity and mortality.
The process is characterized by multiple steps: inflammation, fibrosis, and calcification.
Numerous studies focalized on its physiopathology highlighting different “actors” for the multiple “acts.” This paper focuses on the role of the tumor necrosis factor superfamily (TNFSF) members in the pathogenesis of CAVD.
In particular, we discuss the clinical and experimental studies providing evidence of the involvement of tumor necrosis factor-alpha (TNF-α), receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL), its membrane receptor RANK and its decoy receptor osteoprotegerin (OPG), and TNF-related apoptosis-inducing ligand (TRAIL) in valvular calcification.
American Psychological Association (APA)
Galeone, Antonella& Paparella, Domenico& Colucci, Silvia& Grano, Maria& Brunetti, Giacomina. 2013. The Role of TNF-α and TNF Superfamily Members in the Pathogenesis of Calcific Aortic Valvular Disease. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1013075
Modern Language Association (MLA)
Galeone, Antonella…[et al.]. The Role of TNF-α and TNF Superfamily Members in the Pathogenesis of Calcific Aortic Valvular Disease. The Scientific World Journal No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1013075
American Medical Association (AMA)
Galeone, Antonella& Paparella, Domenico& Colucci, Silvia& Grano, Maria& Brunetti, Giacomina. The Role of TNF-α and TNF Superfamily Members in the Pathogenesis of Calcific Aortic Valvular Disease. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1013075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1013075