Early Second-Trimester Serum MicroRNAs as Potential Biomarker for Nondiabetic Macrosomia
Joint Authors
Hu, Lingmin
Han, Jing
Zheng, Fangxiu
Ma, Hongxia
Chen, Jiaping
Jiang, Yue
Jiang, Hua
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Macrosomia has become a worldwide problem with the rapid economic growth in the past few years.
However, the detailed mechanism of how the macrosomia happened remains unknown.
Growing evidence indicates that miRNAs are involved in maintaining metabolic homeostasis.
We hypothesized that serum miRNAs are potential biomarkers for macrosomia.
Methods.
We performed miRNAs profiling using TLDA chips in the discovery phase in two pooled samples from 30 cases and 30 controls, respectively.
Individual qRT-PCR was conducted for the discovery phase samples.
To confirm the results, we detected the miRNAs which were differentially expressed in the microarray assays and individual qRT-PCR in external validation phase with another 30 cases and 30 controls.
Results.
In the discovery stage, miR-194 and miR-376a expression levels were significantly different between macrosomia group and controls ( P = 0.048 for miR-194 and P = 0.018 for miR-376a, resp.).
Further evaluation of the two miRNAs on a total of 120 serum samples showed that the miR-376a remains significantly lower in macrosomia ( P = 0.032 ).
Receiver operating characteristic curve analyses showed that the area under curve for miR-376a was 67.8% (sensitivity = 96.7% and specificity = 40.0%).
Conclusions.
Serum miR-376a may serve as a potential noninvasive biomarker in detecting macrosomia.
American Psychological Association (APA)
Hu, Lingmin& Han, Jing& Zheng, Fangxiu& Ma, Hongxia& Chen, Jiaping& Jiang, Yue…[et al.]. 2014. Early Second-Trimester Serum MicroRNAs as Potential Biomarker for Nondiabetic Macrosomia. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016267
Modern Language Association (MLA)
Hu, Lingmin…[et al.]. Early Second-Trimester Serum MicroRNAs as Potential Biomarker for Nondiabetic Macrosomia. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1016267
American Medical Association (AMA)
Hu, Lingmin& Han, Jing& Zheng, Fangxiu& Ma, Hongxia& Chen, Jiaping& Jiang, Yue…[et al.]. Early Second-Trimester Serum MicroRNAs as Potential Biomarker for Nondiabetic Macrosomia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016267