Transforming Growth Factor-Beta (TGF-β) Signaling in Paravertebral Muscles in Juvenile and Adolescent Idiopathic Scoliosis
Joint Authors
Mazurek, Urszula
Nowak, Roman
Kwiecien, Magdalena
Tkacz, Magdalena
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Most researchers agree that idiopathic scoliosis (IS) is a multifactorial disease influenced by complex genetic and environmental factors.
The onset of the spinal deformity that determines the natural course of the disease, usually occurs in the juvenile or adolescent period.
Transforming growth factors β (TGF-βs) and their receptors, TGFBRs, may be considered as candidate genes related to IS susceptibility and natural history.
This study explores the transcriptional profile of TGF-βs, TGFBRs, and TGF-β responsive genes in the paravertebral muscles of patients with juvenile and adolescent idiopathic scoliosis (JIS and AIS, resp.).
Muscle specimens were harvested intraoperatively and grouped according to the side of the curve and the age of scoliosis onset.
The results of microarray and qRT-PCR analysis confirmed significantly higher transcript abundances of TGF-β2, TGF-β3, and TGFBR2 in samples from the curve concavity of AIS patients, suggesting a difference in TGF-β signaling in the pathogenesis of juvenile and adolescent curves.
Analysis of TGF-β responsive genes in the transcriptomes of patients with AIS suggested overrepresentation of the genes localized in the extracellular region of curve concavity: LTBP3, LTBP4, ITGB4, and ITGB5.
This finding suggests the extracellular region of paravertebral muscles as an interesting target for future molecular research into AIS pathogenesis.
American Psychological Association (APA)
Nowak, Roman& Kwiecien, Magdalena& Tkacz, Magdalena& Mazurek, Urszula. 2014. Transforming Growth Factor-Beta (TGF-β) Signaling in Paravertebral Muscles in Juvenile and Adolescent Idiopathic Scoliosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016383
Modern Language Association (MLA)
Nowak, Roman…[et al.]. Transforming Growth Factor-Beta (TGF-β) Signaling in Paravertebral Muscles in Juvenile and Adolescent Idiopathic Scoliosis. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1016383
American Medical Association (AMA)
Nowak, Roman& Kwiecien, Magdalena& Tkacz, Magdalena& Mazurek, Urszula. Transforming Growth Factor-Beta (TGF-β) Signaling in Paravertebral Muscles in Juvenile and Adolescent Idiopathic Scoliosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016383