Multifunctional Role of ATMTel1 Kinase in Genome Stability: From the DNA Damage Response to Telomere Maintenance
Joint Authors
Di Domenico, Enea Gino
Romano, Elena
Del Porto, Paola
Ascenzioni, Fiorentina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The mammalian protein kinase ataxia telangiectasia mutated (ATM) is a key regulator of the DNA double-strand-break response and belongs to the evolutionary conserved phosphatidylinositol-3-kinase-related protein kinases.
ATM deficiency causes ataxia telangiectasia (AT), a genetic disorder that is characterized by premature aging, cerebellar neuropathy, immunodeficiency, and predisposition to cancer.
AT cells show defects in the DNA damage-response pathway, cell-cycle control, and telomere maintenance and length regulation.
Likewise, in Saccharomyces cerevisiae, haploid strains defective in the TEL1 gene, the ATM ortholog, show chromosomal aberrations and short telomeres.
In this review, we outline the complex role of ATM/Tel1 in maintaining genomic stability through its control of numerous aspects of cellular survival.
In particular, we describe how ATM/Tel1 participates in the signal transduction pathways elicited by DNA damage and in telomere homeostasis and its importance as a barrier to cancer development.
American Psychological Association (APA)
Di Domenico, Enea Gino& Romano, Elena& Del Porto, Paola& Ascenzioni, Fiorentina. 2014. Multifunctional Role of ATMTel1 Kinase in Genome Stability: From the DNA Damage Response to Telomere Maintenance. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1016561
Modern Language Association (MLA)
Di Domenico, Enea Gino…[et al.]. Multifunctional Role of ATMTel1 Kinase in Genome Stability: From the DNA Damage Response to Telomere Maintenance. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1016561
American Medical Association (AMA)
Di Domenico, Enea Gino& Romano, Elena& Del Porto, Paola& Ascenzioni, Fiorentina. Multifunctional Role of ATMTel1 Kinase in Genome Stability: From the DNA Damage Response to Telomere Maintenance. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1016561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016561