Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair
Joint Authors
Siebert, Justin R.
Conta Steencken, Amanda
Osterhout, Donna J.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central nervous system, serving as guidance cues during development and modulating synaptic connections in the adult.
With injury or disease, an increase in CSPG expression is commonly observed close to lesioned areas.
However, these CSPG deposits form a substantial barrier to regeneration and are largely responsible for the inability to repair damage in the brain and spinal cord.
This review discusses the role of CSPGs as inhibitors, the role of inflammation in stimulating CSPG expression near site of injury, and therapeutic strategies for overcoming the inhibitory effects of CSPGs and creating an environment conducive to nerve regeneration.
American Psychological Association (APA)
Siebert, Justin R.& Conta Steencken, Amanda& Osterhout, Donna J.. 2014. Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1016600
Modern Language Association (MLA)
Siebert, Justin R.…[et al.]. Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1016600
American Medical Association (AMA)
Siebert, Justin R.& Conta Steencken, Amanda& Osterhout, Donna J.. Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1016600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016600