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The CCR5Δ32 Polymorphism in Brazilian Patients with Sickle Cell Disease
Joint Authors
Costa, Fernando Ferreira
Lopes, Mariana Pezzute
Santos, Magnun Nueldo Nunes
Faber, Eliel Wagner
Bezerra, Marcos André Cavalcanti
Hatzlhofer, Betânia Lucena Domingues
Albuquerque, Dulcinéia Martins
Zaccariotto, Tânia Regina
Ribeiro, Daniela Maria
Araújo, Aderson da Silva
Sonati, M. F.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Previous studies on the role of inflammation in the pathophysiology of sickle cell disease (SCD) suggested that the CCR5Δ32 allele, which is responsible for the production of truncated C-C chemokine receptor type 5 (CCR5), could confer a selective advantage on patients with SCD because it leads to a less efficient Th1 response.
We determined the frequency of the CCR5Δ32 polymorphism in 795 Afro-Brazilian SCD patients followed up at the Pernambuco Hematology and Hemotherapy Center, in Northeastern Brazil, divided into a pediatric group (3 months–17 years, n=483) and an adult group (18–70 years, n=312).
The adult patients were also compared to a healthy control group (blood donors, 18–61 years, n=247).
Methods.
The CCR5/CCR5Δ32 polymorphism was determined by allele-specific PCR.
Results.
No homozygous patient for the CCR5Δ32 allele was detected.
The frequency of heterozygotes in the study population (patients and controls) was 5.8%, in the total SCD patients 5.1%, in the children 5.4%, in the adults with SCD 4.8%, and in the adult controls 8.1%.
These differences did not reach statistical significance.
Conclusions.
Our findings failed to demonstrate an important role of the CCR5Δ32 allele in the population sample studied here.
American Psychological Association (APA)
Lopes, Mariana Pezzute& Santos, Magnun Nueldo Nunes& Faber, Eliel Wagner& Bezerra, Marcos André Cavalcanti& Hatzlhofer, Betânia Lucena Domingues& Albuquerque, Dulcinéia Martins…[et al.]. 2014. The CCR5Δ32 Polymorphism in Brazilian Patients with Sickle Cell Disease. Disease Markers،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1018023
Modern Language Association (MLA)
Lopes, Mariana Pezzute…[et al.]. The CCR5Δ32 Polymorphism in Brazilian Patients with Sickle Cell Disease. Disease Markers No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1018023
American Medical Association (AMA)
Lopes, Mariana Pezzute& Santos, Magnun Nueldo Nunes& Faber, Eliel Wagner& Bezerra, Marcos André Cavalcanti& Hatzlhofer, Betânia Lucena Domingues& Albuquerque, Dulcinéia Martins…[et al.]. The CCR5Δ32 Polymorphism in Brazilian Patients with Sickle Cell Disease. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1018023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018023