New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid- β -Induced Progression of Tau Phosphorylation and Axonal Atrophy
Joint Authors
Tohda, Chihiro
Watari, Hidetoshi
Shimada, Yutaka
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
We previously reported that kamikihito (KKT), a traditional Japanese medicine, improved memory impairment and reversed the degeneration of axons in the 5XFAD mouse model of Alzheimer’s disease (AD).
However, the mechanism underlying the effects of KKT remained unknown.
The aim of the present study was to investigate the mechanism by which KKT reverses the progression of axonal degeneration.
Methods.
Primary cultured cortical neurons were treated with amyloid beta (Aβ) fragment comprising amino acid residues (25–35) (10 μM) in an in vitro AD model.
KKT (10 μg/mL) was administered to the cells before or after Aβ treatment.
The effects of KKT on Aβ-induced tau phosphorylation, axonal atrophy, and protein phosphatase 2A (PP2A) activity were investigated.
We also performed an in vivo assay in which KKT (500 mg/kg/day) was administered to 5XFAD mice once a day for 15 days.
Cerebral cortex homogenates were used to measure PP2A activity.
Results.
KKT improved Aβ-induced tau phosphorylation and axonal atrophy after they had already progressed.
In addition, KKT increased PP2A activity in vitro and in vivo.
Conclusions.
KKT reversed the progression of Aβ-induced axonal degeneration.
KKT reversed axonal degeneration at least in part through its role as an exogenous PP2A stimulator.
American Psychological Association (APA)
Watari, Hidetoshi& Shimada, Yutaka& Tohda, Chihiro. 2014. New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid- β -Induced Progression of Tau Phosphorylation and Axonal Atrophy. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018919
Modern Language Association (MLA)
Watari, Hidetoshi…[et al.]. New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid- β -Induced Progression of Tau Phosphorylation and Axonal Atrophy. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018919
American Medical Association (AMA)
Watari, Hidetoshi& Shimada, Yutaka& Tohda, Chihiro. New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid- β -Induced Progression of Tau Phosphorylation and Axonal Atrophy. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018919