Protective effects of palm date and apricot kernels powder in carbon tetra chloride-induced liver disorder in rats

Abstract EN

Effects of some levels 2.5 and 5 % of apricot, palm date kernels and their mixture as powder on biological and biochemical changes of hepatic rats were evaluated.

Forty-eight white male albino rats weighing 140±10g were used in this study.

Rats divided to 8 groups, each group (6) rats.

Hepatotoxicity was induced in rats by injecting carbon tetrachloride (CCl₄) 0.2 ml/100 g body weight of 40 ml/l CCl₄ dissolved in paraffin oil.

Identification of phenolic compounds was determined using HPLC technique, serum liver Enzyme such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VIDL-c), kidney functions (uric acid, urea and creatinine), oxidative enzymes such as glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activity were also determined.

The obtained results of hepatic rats indicated that apricot, palm date kernels powder and their mixture improve serum liver functions, kidney functions, lipids profile and oxidative enzymes in rats especially 5% mixture of apricot and palm date kernels powder.

The HPLC results showed that the apricot kernels contained higher bioactive compounds than palm date.

Results also indicated that mixture of apricot, palm date kernels powder recorded the best treatment for improved all tested biochemical analysis.

Therefore, apricot and palm kernels powder and their mixture could be used in our beverages and daily dishes, because it has so many health benefits.