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PPAR-γ Thiazolidinedione Agonists and Immunotherapy in the Treatment of Brain Tumors
Joint Authors
Spagnolo, Alessandra
Glick, Roberta P.
Feinstein, Douglas L.
Lichtor, Terry
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Thiazolidinediones (TZDs) are selective agonists of the peroxisome proliferator-activated receptor (PPAR) gamma, a transcription factor belonging to the superfamily of nuclear hormone receptors.
Although activation of PPARγ by TZDs has been best characterized by its ability to regulate expression of genes associated with lipid metabolism, PPARγ agonists have other physiological effects including modulating pro- and anti-inflammatory gene expression and inducing apoptosis in several cell types including glioma cells and cell lines.
Immunotherapeutic approaches to reducing brain tumors are focused on means to reduce the immunosuppressive responses of tumors which dampen the ability of cytotoxic T-lymphocytes to kill tumors.
Initial studies from our lab show that combination of an immunotherapeutic strategy with TZD treatment provides synergistic benefit in animals with implanted tumors.
The potential of this combined approach for treatment of brain tumors is reviewed in this report.
American Psychological Association (APA)
Lichtor, Terry& Spagnolo, Alessandra& Glick, Roberta P.& Feinstein, Douglas L.. 2008. PPAR-γ Thiazolidinedione Agonists and Immunotherapy in the Treatment of Brain Tumors. PPAR Research،Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-1027063
Modern Language Association (MLA)
Lichtor, Terry…[et al.]. PPAR-γ Thiazolidinedione Agonists and Immunotherapy in the Treatment of Brain Tumors. PPAR Research No. 2008 (2008), pp.1-4.
https://search.emarefa.net/detail/BIM-1027063
American Medical Association (AMA)
Lichtor, Terry& Spagnolo, Alessandra& Glick, Roberta P.& Feinstein, Douglas L.. PPAR-γ Thiazolidinedione Agonists and Immunotherapy in the Treatment of Brain Tumors. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-1027063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027063