Do PPARγ Ligands Suppress the Growth of Cholangiocarcinoma or the Cholangiohepatitis Induced by the Tumor?
Joint Authors
Hashizume, Kiyoshi
Suzuki, Satoru
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Cholangiocarcinoma is a predominantly fatal cancer, which can be difficult to treat.
It has been reported that the administration of pioglitazone temporarily improved not only diabetic control, but also bile duct carcinoma-induced cholangiohepatitis.
Pioglitazone is considered to have both direct and indirect mechanisms of action on the tumor-related hepatitis.
Several molecules induced by thiazolidinedione, including Smad pathway-related molecules, adipokines, and other lipid metabolism-related proteins, may directly or indirectly suppress tumor development and/or tumor-induced cholangiohepatitis.
Although the most frequent and critical side effect of thiazolidinedione is drug-induced hepatitis, it can probably be avoided by careful monitoring of serum hepatic enzyme levels.
Thiazolidinedione should be considered for management of tumor-induced hepatitis in the presence of diabetes unless severe side effects occur.
American Psychological Association (APA)
Suzuki, Satoru& Hashizume, Kiyoshi. 2008. Do PPARγ Ligands Suppress the Growth of Cholangiocarcinoma or the Cholangiohepatitis Induced by the Tumor?. PPAR Research،Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-1027064
Modern Language Association (MLA)
Suzuki, Satoru& Hashizume, Kiyoshi. Do PPARγ Ligands Suppress the Growth of Cholangiocarcinoma or the Cholangiohepatitis Induced by the Tumor?. PPAR Research No. 2008 (2008), pp.1-4.
https://search.emarefa.net/detail/BIM-1027064
American Medical Association (AMA)
Suzuki, Satoru& Hashizume, Kiyoshi. Do PPARγ Ligands Suppress the Growth of Cholangiocarcinoma or the Cholangiohepatitis Induced by the Tumor?. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-1027064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027064