Interaction between α-Synuclein and Other Proteins in Neurodegenerative Disorders
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Protein aggregation is a common characteristic of many neurodegenerative disorders, and the interaction between pathological/toxic proteins to cause neurodegeneration is a hot topic of current neuroscience research.
Despite clinical, genetic, and experimental differences, evidence increasingly indicates considerable overlap between synucleinopathies and tauopathies or other protein-misfolding diseases.
Inclusions, characteristics of these disorders, also occurring in other neurodegenerative diseases, suggest interactions of pathological proteins engaging common downstream pathways.
Novel findings that have shifted our understanding in the role of pathologic proteins in the pathogenesis of Parkinson and Alzheimer diseases have confirmed correlations/overlaps between these and other neurodegenerative disorders.
The synergistic effects of α-synuclein, hyperphosphorylated tau, amyloid-β, and other pathologic proteins, and the underlying molecular pathogenic mechanisms, including induction and spread of protein aggregates, are critically reviewed, suggesting a dualism or triad of neurodegeneration in protein-misfolding disorders, although the etiology of most of these processes is still mysterious.
American Psychological Association (APA)
Jellinger, Kurt A.. 2011. Interaction between α-Synuclein and Other Proteins in Neurodegenerative Disorders. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-1027871
Modern Language Association (MLA)
Jellinger, Kurt A.. Interaction between α-Synuclein and Other Proteins in Neurodegenerative Disorders. The Scientific World Journal No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-1027871
American Medical Association (AMA)
Jellinger, Kurt A.. Interaction between α-Synuclein and Other Proteins in Neurodegenerative Disorders. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-1027871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027871