Two Different Isomers of Vitamin E Prevent Bone Loss in Postmenopausal Osteoporosis Rat Model
Joint Authors
Ima-Nirwana, Soelaiman
Luke, Douglas Alwyn
Shuid, Ahmad Nazrun
Mohamed, Norazlina
Muhammad, Norliza
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Postmenopausal osteoporotic bone loss occurs mainly due to cessation of ovarian function, a condition associated with increased free radicals.
Vitamin E, a lipid-soluble vitamin, is a potent antioxidant which can scavenge free radicals in the body.
In this study, we investigated the effects of alpha-tocopherol and pure tocotrienol on bone microarchitecture and cellular parameters in ovariectomized rats.
Three-month-old female Wistar rats were randomly divided into ovariectomized control, sham-operated, and ovariectomized rats treated with either alpha-tocopherol or tocotrienol.
Their femurs were taken at the end of the four-week study period for bone histomorphometric analysis.
Ovariectomy causes bone loss in the control group as shown by reduction in both trabecular volume (BV/TV) and trabecular number (Tb.N) and an increase in trabecular separation (Tb.S).
The increase in osteoclast surface (Oc.S) and osteoblast surface (Ob.S) in ovariectomy indicates an increase in bone turnover rate.
Treatment with either alpha-tocopherol or tocotrienol prevents the reduction in BV/TV and Tb.N as well as the increase in Tb.S, while reducing the Oc.S and increasing the Ob.S.
In conclusion, the two forms of vitamin E were able to prevent bone loss due to ovariectomy.
Both tocotrienol and alpha-tocopherol exert similar effects in preserving bone microarchitecture in estrogen-deficient rat model.
American Psychological Association (APA)
Muhammad, Norliza& Luke, Douglas Alwyn& Shuid, Ahmad Nazrun& Mohamed, Norazlina& Ima-Nirwana, Soelaiman. 2012. Two Different Isomers of Vitamin E Prevent Bone Loss in Postmenopausal Osteoporosis Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028131
Modern Language Association (MLA)
Muhammad, Norliza…[et al.]. Two Different Isomers of Vitamin E Prevent Bone Loss in Postmenopausal Osteoporosis Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028131
American Medical Association (AMA)
Muhammad, Norliza& Luke, Douglas Alwyn& Shuid, Ahmad Nazrun& Mohamed, Norazlina& Ima-Nirwana, Soelaiman. Two Different Isomers of Vitamin E Prevent Bone Loss in Postmenopausal Osteoporosis Rat Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028131