![](/images/graphics-bg.png)
Effect of Treatment with Cyanidin-3-O-β-D-Glucoside on Rat IschemicReperfusion Brain Damage
Joint Authors
Di Giacomo, Claudia
Acquaviva, Rosaria
Santangelo, Rosa
Sorrenti, Valeria
Li Volti, Giovanni
D'Orazio, Nicolantonio
Vanella, Angelo
Galvano, Fabio
Vanella, Luca
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study investigated the effect of cyanidin-3-O-β-glucoside on an experimental model of partial/transient cerebral ischemia in the rats in order to verify the effectiveness of both pre- and posttreatments.
Cyanidin-3-O-β-glucoside-pretreated rats were injected with 10 mg/Kg i.p.
1 h before the induction of cerebral ischemia; in posttreated rats, the same dosage was injected during reperfusion (30 min after restoring blood flow).
Cerebral ischemia was induced by bilateral clamping of common carotid arteries for 20 min.
Ischemic rats were sacrificed immediately after 20 min ischemia; postischemic reperfused animals were sacrificed after 3 or 24 h of restoring blood flow.
Results showed that treatment with cyanidin increased the levels of nonproteic thiol groups after 24 h of postischemic reperfusion, significantly reduced the lipid hydroperoxides, and increased the expression of heme oxygenase and γ-glutamyl cysteine synthase; a significant reduction in the expression of neuronal and inducible nitric oxide synthases and the equally significant increase in the endothelial isoform were observed.
Significant modifications were also detected in enzymes involved in metabolism of endogenous inhibitors of nitric oxide.
Most of the effects were observed with both pre- and posttreatments with cyanidin-3-O-β-glucoside suggesting a role of anthocyanin in both prevention and treatment of postischemic reperfusion brain damage.
American Psychological Association (APA)
Di Giacomo, Claudia& Acquaviva, Rosaria& Santangelo, Rosa& Sorrenti, Valeria& Vanella, Luca& Li Volti, Giovanni…[et al.]. 2012. Effect of Treatment with Cyanidin-3-O-β-D-Glucoside on Rat IschemicReperfusion Brain Damage. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028233
Modern Language Association (MLA)
Di Giacomo, Claudia…[et al.]. Effect of Treatment with Cyanidin-3-O-β-D-Glucoside on Rat IschemicReperfusion Brain Damage. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028233
American Medical Association (AMA)
Di Giacomo, Claudia& Acquaviva, Rosaria& Santangelo, Rosa& Sorrenti, Valeria& Vanella, Luca& Li Volti, Giovanni…[et al.]. Effect of Treatment with Cyanidin-3-O-β-D-Glucoside on Rat IschemicReperfusion Brain Damage. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028233