The ent-15α-Acetoxykaur-16-en-19-oic Acid Relaxes Rat Artery Mesenteric Superior via Endothelium-Dependent and Endothelium-Independent Mechanisms
Joint Authors
Ribeiro, Êurica Adélia Nogueira
Herculano, Edla de Azevedo
Costa, Cintia Danieli Ferreira da
Furtado, Fabiola Fialho
da-Cunha, Emídio Vasconcelos Leitão
Barbosa-Filho, José Maria
da Silva, Marcelo Sobral
Medeiros, Isac Almeida de
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of the study was to investigate the mechanism of the relaxant activity of the ent-15α-acetoxykaur-16-en-19-oic acid (KA-acetoxy).
In rat mesenteric artery rings, KA-acetoxy induced a concentration-dependent relaxation in vessels precontracted with phenylephrine.
In the absence of endothelium, the vasorelaxation was significantly shifted to the right without reduction of the maximum effect.
Endothelium-dependent relaxation was significantly attenuated by pretreatment with L-NAME, an inhibitor of the NO-synthase (NOS), indomethacin, an inhibitor of the cyclooxygenase, L-NAME + indomethacin, atropine, a nonselective antagonist of the muscarinic receptors, ODQ, selective inhibitor of the guanylyl cyclase enzyme, or hydroxocobalamin, a nitric oxide scavenger.
The relaxation was completely reversed in the presence of L-NAME + 1 mM L-arginine or L-arginine, an NO precursor.
Diterpene-induced relaxation was not affected by TEA, a nonselective inhibitor of K+ channels.
The KA-acetoxy antagonized CaCl2-induced contractions in a concentration-dependent manner and also inhibited an 80 mM KCl-induced contraction.
The KA-acetoxy did not interfere with Ca2+ release from intracellular stores.
The vasorelaxant induced by KA-acetoxy seems to involve the inhibition of the Ca2+ influx and also, at least in part, by endothelial muscarinic receptors activation, NO and PGI2 release.
American Psychological Association (APA)
Ribeiro, Êurica Adélia Nogueira& Herculano, Edla de Azevedo& Costa, Cintia Danieli Ferreira da& Furtado, Fabiola Fialho& da-Cunha, Emídio Vasconcelos Leitão& Barbosa-Filho, José Maria…[et al.]. 2012. The ent-15α-Acetoxykaur-16-en-19-oic Acid Relaxes Rat Artery Mesenteric Superior via Endothelium-Dependent and Endothelium-Independent Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028329
Modern Language Association (MLA)
Ribeiro, Êurica Adélia Nogueira…[et al.]. The ent-15α-Acetoxykaur-16-en-19-oic Acid Relaxes Rat Artery Mesenteric Superior via Endothelium-Dependent and Endothelium-Independent Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028329
American Medical Association (AMA)
Ribeiro, Êurica Adélia Nogueira& Herculano, Edla de Azevedo& Costa, Cintia Danieli Ferreira da& Furtado, Fabiola Fialho& da-Cunha, Emídio Vasconcelos Leitão& Barbosa-Filho, José Maria…[et al.]. The ent-15α-Acetoxykaur-16-en-19-oic Acid Relaxes Rat Artery Mesenteric Superior via Endothelium-Dependent and Endothelium-Independent Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028329