Biological Activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod Preparations
Joint Authors
Barroso Coelho, Luana Cassandra Breitenbach
Nascimento, Silene Carneiro do
Freitas, A. C. C.
Ximenes, N. C. A.
Aguiar, J. S.
Lins, T. U. L.
Magalhães, L. R.
Carneiro-da-Cunha, M. G.
Correia, M. T. S.
da Silva, Teresinha Gonçalves
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Libidibia ferrea has been used in folk medicine throughout Brazil, and this study evaluated the biological activities of crude extract (CE) as well as a partially purified fraction (F80) obtained from its pods.
Results from the MTT assay revealed that only F80 inhibited NCI-H292 cell growth; however, neither CE nor F80 reduced HEp-2 cell growth or sarcoma 180 tumor weight with the in vivo assay.
Acute oral toxicity of the extract and fraction was evaluated following the steps of Guideline 423, using female mice; LD50 for both preparations was determined as 2,500 mg/kg body weight.
CE and F80 promoted a reduction of the leukocyte number and nitrite level in inflammatory exudates when the anti-inflammatory assay (carrageenan-induced peritonitis) was performed.
CE and F80 inhibited writhing regarding antinociceptive activity (acetic acid-induced writhing response in mice).
In conclusion, CE and F80 have no significant cytotoxic or antitumor activities in cell lines showing low toxicity and no action against tumors in vivo.
Both preparations revealed anti-inflammatory and antinociceptive activities, corroborating the pharmacological basis of L.
ferrea for ethnomedical use.
American Psychological Association (APA)
Freitas, A. C. C.& Ximenes, N. C. A.& Aguiar, J. S.& Nascimento, Silene Carneiro do& Lins, T. U. L.& Magalhães, L. R.…[et al.]. 2012. Biological Activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod Preparations. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028372
Modern Language Association (MLA)
Freitas, A. C. C.…[et al.]. Biological Activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod Preparations. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028372
American Medical Association (AMA)
Freitas, A. C. C.& Ximenes, N. C. A.& Aguiar, J. S.& Nascimento, Silene Carneiro do& Lins, T. U. L.& Magalhães, L. R.…[et al.]. Biological Activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod Preparations. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028372