A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors
Joint Authors
Xiu, Lijuan
Huang, Yi
Meng, Xian-Ze
Wu, Feng
Wei, Pin-Kang
Pang, Bin
Sun, Da-Zhi
Qin, Zhi-Feng
Shi, Jun
Lao, Lixing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Posttraumatic stress disorder (PTSD) is accompanied by poor general psychological status (GPS).
In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD.
Methods.
A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula, Xiao-Tan-Jie-Yu-Fang (XTJYF), to placebo in 2008 Sichuan earthquake survivors with PTSD.
Patients were randomized into XTJYF (n=123) and placebo (n=122) groups.
Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R) and rates of response in the SCL global severity index (GSI) were the primary endpoints.
A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints.
Results and Discussion.
Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices (P = 0.001~0.028).
More patients in the XTJYF group reported “much improved” than the placebo group (P = 0.001).
The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility (P = 0.001~0.036)), and in sleep quality score (P<0.001).
XTJYF produced no serious adverse events.
These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD.
American Psychological Association (APA)
Meng, Xian-Ze& Wu, Feng& Wei, Pin-Kang& Xiu, Lijuan& Shi, Jun& Pang, Bin…[et al.]. 2011. A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028472
Modern Language Association (MLA)
Meng, Xian-Ze…[et al.]. A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028472
American Medical Association (AMA)
Meng, Xian-Ze& Wu, Feng& Wei, Pin-Kang& Xiu, Lijuan& Shi, Jun& Pang, Bin…[et al.]. A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028472