Regulation of Proinflammatory Mediators via NF-κB and p38 MAPK-Dependent Mechanisms in RAW 264.7 Macrophages by Polyphenol Components Isolated from Korea Lonicera japonica THUNB
Joint Authors
Lee, Won-Sup
Park, Kwang-Il
Chung, Hyon-Jong
An, Su-Jin
Shin, Sung Chul
Kim, Jin-A.
Kim, Gon-Sup
Park, Hyeon-Soo
Lee, Do Hoon
Kim, Eun-Hee
Nagappan, Arulkumar
Kang, Sang-Rim
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lonicera japonica THUNB., which abundantly contains polyphenols, has been used as a traditional medicine for thousands of years in East Asian countries because of the anti-inflammation properties.
This study aimed to investigate the anti-inflammatory mechanism of polyphenol components isolated from Korea L.
japonica T.
by nuclear factor-kappaB (NF-κB) and mitogen-activated protein kinases (MAPKs) pathway.
Polyphenols significantly decreased lipopolysaccharide- (LPS-) induced mRNA and protein expression of inducible nitric oxide synthase and cyclooxygenase-2, as well as mRNA expression of tumor necrosis factor-alpha, interleukin- (IL-) 1β, and IL-6.
Moreover, polyphenols inhibited nuclear translocation of NF-κB p65, phosphorylation/degradation of the inhibitor of κB, and phosphorylation of p38 MAPK, whereas the extracellular signal-regulated kinase and Janus N-terminal kinase were not affected.
These results indicate that polyphenol components isolated from Korea L.
japonica T.
should have anti-inflammatory effect on LPS-stimulated RAW 264.7 cells through the decrease of proinflammatory mediators expression by suppressing NF-κB and p38 MAPK activity.
American Psychological Association (APA)
Park, Kwang-Il& Kang, Sang-Rim& Park, Hyeon-Soo& Lee, Do Hoon& Nagappan, Arulkumar& Kim, Jin-A.…[et al.]. 2012. Regulation of Proinflammatory Mediators via NF-κB and p38 MAPK-Dependent Mechanisms in RAW 264.7 Macrophages by Polyphenol Components Isolated from Korea Lonicera japonica THUNB. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028567
Modern Language Association (MLA)
Park, Kwang-Il…[et al.]. Regulation of Proinflammatory Mediators via NF-κB and p38 MAPK-Dependent Mechanisms in RAW 264.7 Macrophages by Polyphenol Components Isolated from Korea Lonicera japonica THUNB. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028567
American Medical Association (AMA)
Park, Kwang-Il& Kang, Sang-Rim& Park, Hyeon-Soo& Lee, Do Hoon& Nagappan, Arulkumar& Kim, Jin-A.…[et al.]. Regulation of Proinflammatory Mediators via NF-κB and p38 MAPK-Dependent Mechanisms in RAW 264.7 Macrophages by Polyphenol Components Isolated from Korea Lonicera japonica THUNB. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028567