In Vitro Characterization of Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery

Joint Authors

Butt, Adeel Masood
Sarisuta, Narong
Witoonsaridsilp, Wasu
Benjakul, Ruthairat
Katas, Haliza
Mohd Amin, Mohd Cairul Iqbal

Source

Journal of Nanomaterials

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-09-25

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Chemistry
Civil Engineering

Abstract EN

Mixed micelles of Pluronic F127 and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) in different molar ratios (10 : 0, 7 : 3, 5 : 5, and 3 : 7) were prepared to characterize this system as nanocarriers for targeted delivery of chemotherapeutic agents.

Their size, zeta potential, critical micelle concentration, drug loading content, entrapment efficiency, drug release, cytotoxicity, and stability in serum were evaluated in vitro by using doxorubicin as the model anticancer drug.

The micellar sizes ranged from 25 to 35 nm.

The 7 : 3 and 5 : 5 micellar combinations had lower critical micelle concentrations (5×10−5 M) than the 10 : 0 combination (5×10−4 M).

The entrapment efficiencies of the 7 : 3, 5 : 5, and 3 : 7 micellar combinations were 72%, 88%, and 69%, respectively.

Doxorubicin release was greater at acidic tumour pH than at normal physiological pH.

The doxorubicin-loaded mixed micelles showed greater percent inhibition and apoptosis activity in human breast adenocarcinoma (MCF-7) and acute monocytic leukaemia (THP-1) cell lines than free doxorubicin did.

The mixed micelles were also stable against aggregation and precipitation in serum.

These findings suggest that Pluronic F127-TPGS mixed micelles could be used as nanocarriers for targeted anticancer-drug delivery.

American Psychological Association (APA)

Butt, Adeel Masood& Mohd Amin, Mohd Cairul Iqbal& Katas, Haliza& Sarisuta, Narong& Witoonsaridsilp, Wasu& Benjakul, Ruthairat. 2012. In Vitro Characterization of Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029318

Modern Language Association (MLA)

Butt, Adeel Masood…[et al.]. In Vitro Characterization of Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery. Journal of Nanomaterials No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1029318

American Medical Association (AMA)

Butt, Adeel Masood& Mohd Amin, Mohd Cairul Iqbal& Katas, Haliza& Sarisuta, Narong& Witoonsaridsilp, Wasu& Benjakul, Ruthairat. In Vitro Characterization of Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029318

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1029318