Mobilization of CD34+CXCR4+ StemProgenitor Cells and the Parameters of Left Ventricular Function and Remodeling in 1-Year Follow-up of Patients with Acute Myocardial Infarction

Abstract EN

Mobilization of stem cells in acute MI might signify the reparatory response.

Aim of the Study.

Prospective evaluation of correlation between CD34+CXCR4+ cell mobilization and improvement of LVEF and remodeling in patients with acute MI in 1-year followup.

Methods.

50 patients with MI, 28 with stable angina (SAP), and 20 individuals with no CAD (CTRL).

CD34+CXCR4+ cells, SDF-1, G-CSF, troponin I (TnI) and NT-proBNP were measured on admission and 1 year after MI.

Echocardiography and ergospirometry were carried out after 1 year.

Results.

Number of CD34+CXCR4+ cells in acute MI was significantly higher in comparison with SAP and CTRL, but lower in patients with decreased LVEF ≤40%.

In patients who had significant LVEF increase ≥5% in 1 year FU the number of cells in acute MI was significantly higher versus patients with no LVEF improvement.

Number of cells was positively correlated (r=0,41, P=0,031) with absolute LVEF change and inversely with absolute change of ESD and EDD in 1-year FU.

Mobilization of CD34+CXCR4+ cells in acute MI was negatively correlated with maximum TnI and NT-proBNP levels.

Conclusion.

Mobilization of CD34+CXCR4+ cells in acute MI shows significant positive correlation with improvement of LVEF after 1 year.