High-Mobility Group Box-1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy
Joint Authors
Nawaz, Mohd Imtiaz
Abu El-Asrar, Ahmed M.
Abouammoh, Marwan
Kangave, Dustan
Mohammad, Ghulam
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to measure the levels of high-mobility group box-1 (HMGB1) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR) and to correlate its levels with clinical disease activity and the levels of vascular endothelial growth factor (VEGF), the angiogenic cytokine granulocyte-colony-stimulating factor (G-CSF), the endothelial cell angiogenic markers soluble vascular endothelial-cadherin (sVE-cadherin), and soluble endoglin (sEng).
Vitreous samples from 36 PDR and 21 nondiabetic patients were studied by enzyme-linked immunosorbent assay.
HMGB1, VEGF, sVE-cadherin, and sEng levels were significantly higher in PDR patients than in nondiabetics (P=0.008; <0.001; <0.001; 0.003, resp.).
G-CSF was detected in only 3 PDR samples.
In the whole study group, there was significant positive correlation between the levels of HMGB1, and sVE-cadherin (r=0.378, P=0.007).
In PDR patients, there was significant negative correlation between the levels of sVE-cadherin and sEng (r=−0.517, P=0.0005).
Exploratory regression analysis identified significant associations between active PDR and high levels of VEGF (odds ratio = 76.4; 95% confidence interval = 6.32–923) and high levels of sEng (odds ratio = 6.01; 95% confidence interval = 1.25–29.0).
Our findings suggest that HMGB1, VEGF, sVE-cadherin and sEng regulate the angiogenesis in PDR.
American Psychological Association (APA)
Abu El-Asrar, Ahmed M.& Nawaz, Mohd Imtiaz& Kangave, Dustan& Abouammoh, Marwan& Mohammad, Ghulam. 2012. High-Mobility Group Box-1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029429
Modern Language Association (MLA)
Abu El-Asrar, Ahmed M.…[et al.]. High-Mobility Group Box-1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029429
American Medical Association (AMA)
Abu El-Asrar, Ahmed M.& Nawaz, Mohd Imtiaz& Kangave, Dustan& Abouammoh, Marwan& Mohammad, Ghulam. High-Mobility Group Box-1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029429