PPARs: Interference with Warburg’ Effect and Clinical Anticancer Trials
Joint Authors
Porchet, Nicole
Rocchi, Stéphane
Colet, Jean-Marie
Briand, Gilbert
Vanden Eynde, Jean Jacques
Vamecq, Joseph
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The metabolic/cell signaling basis of Warburg’s effect (“aerobic glycolysis”) and the general metabolic phenotype adopted by cancer cells are first reviewed.
Several bypasses are adopted to provide a panoramic integrated view of tumoral metabolism, by attributing a central signaling role to hypoxia-induced factor (HIF-1) in the expression of aerobic glycolysis.
The cancer metabolic phenotype also results from alterations of other routes involving ras, myc, p53, and Akt signaling and the propensity of cancer cells to develop signaling aberrances (notably aberrant surface receptor expression) which, when present, offer unique opportunities for therapeutic interventions.
The rationale for various emerging strategies for cancer treatment is presented along with mechanisms by which PPAR ligands might interfere directly with tumoral metabolism and promote anticancer activity.
Clinical trials using PPAR ligands are reviewed and followed by concluding remarks and perspectives for future studies.
A therapeutic need to associate PPAR ligands with other anticancer agents is perhaps an important lesson to be learned from the results of the clinical trials conducted to date.
American Psychological Association (APA)
Vamecq, Joseph& Colet, Jean-Marie& Vanden Eynde, Jean Jacques& Briand, Gilbert& Porchet, Nicole& Rocchi, Stéphane. 2012. PPARs: Interference with Warburg’ Effect and Clinical Anticancer Trials. PPAR Research،Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-1029984
Modern Language Association (MLA)
Vamecq, Joseph…[et al.]. PPARs: Interference with Warburg’ Effect and Clinical Anticancer Trials. PPAR Research No. 2012 (2012), pp.1-23.
https://search.emarefa.net/detail/BIM-1029984
American Medical Association (AMA)
Vamecq, Joseph& Colet, Jean-Marie& Vanden Eynde, Jean Jacques& Briand, Gilbert& Porchet, Nicole& Rocchi, Stéphane. PPARs: Interference with Warburg’ Effect and Clinical Anticancer Trials. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-1029984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029984