Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
Joint Authors
Kretsovali, A.
Hadjimichael, Christiana
Charmpilas, Nikolaos
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis.
Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells.
In addition, they can promote directed differentiation of embryonic and tissue-specific stem cells along the neuronal, cardiomyocytic, and hepatic lineages.
They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors.
In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4.
Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency.
Deciphering the mechanisms of HDAC inhibitor actions is very important to enable their exploitation for efficient and simple tissue regeneration therapies.
American Psychological Association (APA)
Kretsovali, A.& Hadjimichael, Christiana& Charmpilas, Nikolaos. 2012. Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming. Stem Cells International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1030002
Modern Language Association (MLA)
Kretsovali, A.…[et al.]. Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming. Stem Cells International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1030002
American Medical Association (AMA)
Kretsovali, A.& Hadjimichael, Christiana& Charmpilas, Nikolaos. Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1030002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030002