HLA-B*40 Allele Plays a Role in the Development of Acute Leukemia in Mexican Population: A Case-Control Study
Joint Authors
Granados, Julio
Fernández-Torres, Javier
Flores-Jiménez, Denhi
Arroyo-Pérez, Antonio
López-Reyes, Alberto
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Among oncohematological diseases, acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML) are characterized by the uncontrolled production and accumulation of blasts that can lead to death.
Although the physiopathology of these diseases is multifactorial, a genetic factor seems to be at play.
Several studies worldwide have shown association of ALL and AML with several alleles of the major histocompatibility complex (MHC).
Objective.
To determine gene frequencies of HLA-B alleles in Mexicans (individuals with Native American genetic background admixed with European descent) with ALL and AML.
Methods.
We compared the HLA-B alleles in 213 patients with ALL and 85 patients with AML to those present in 731 umbilical cord blood (UCB) samples as a control group; this was done by means of the PCR-SSP technique.
Results.
We found an increased frequency of the HLA-B*40 allele in ALL patients as compared to the control group (14.5% versus 9.84%, P=0.003, OR = 1.67); this was particularly evident in a subgroup of young (less than 18 years old) ALL patients (P=0.002, OR = 1.76); likewise, a decreased frequency of HLA-B*40 allele in AML patients was observed as compared to the control group (4.70% versus 9.84%, P=0.02, OR = 0.42).
Conclusions.
These results might suggest opposing effects of the HLA-B*40 in the genetic susceptibility to develop ALL or AML and offer the possibility to study further the molecular mechanisms of cell differentiation within the bone marrow lineage.
American Psychological Association (APA)
Fernández-Torres, Javier& Flores-Jiménez, Denhi& Arroyo-Pérez, Antonio& Granados, Julio& López-Reyes, Alberto. 2013. HLA-B*40 Allele Plays a Role in the Development of Acute Leukemia in Mexican Population: A Case-Control Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030821
Modern Language Association (MLA)
Fernández-Torres, Javier…[et al.]. HLA-B*40 Allele Plays a Role in the Development of Acute Leukemia in Mexican Population: A Case-Control Study. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030821
American Medical Association (AMA)
Fernández-Torres, Javier& Flores-Jiménez, Denhi& Arroyo-Pérez, Antonio& Granados, Julio& López-Reyes, Alberto. HLA-B*40 Allele Plays a Role in the Development of Acute Leukemia in Mexican Population: A Case-Control Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030821