Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats
Joint Authors
Jaafar, Hasnan
Hassan, Asma’
Mohd Hilmi, Abu Bakar
Asiah, Abu Bakar
Halim, Ahmad Sukari
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Wounds with full-thickness skin loss are commonly managed by skin grafting.
In the absence of a graft, reepithelialization is imperfect and leads to increased scar formation.
Biomaterials can alter wound healing so that it produces more regenerative tissue and fewer scars.
This current study use the new chitosan based biomaterial in full-thickness wound with impaired healing on rat model.
Wounds were evaluated after being treated with a chitosan dermal substitute, a chitosan skin substitute, or duoderm CGF.
Wounds treated with the chitosan skin substitute showed the most re-epithelialization (33.2 ± 2.8%), longest epithelial tongue (1.62 ± 0.13 mm), and shortest migratory tongue distance (7.11 ± 0.25 mm).
The scar size of wounds treated with the chitosan dermal substitute (0.13 ± 0.02 cm) and chitosan skin substitute (0.16 ± 0.05 cm) were significantly decreased (P<0.05) compared with duoderm (0.45 ± 0.11 cm).
Human leukocyte antigen (HLA) expression on days 7, 14, and 21 revealed the presence of human hair follicle stem cells and fibroblasts that were incorporated into and surviving in the irradiated wound.
We have proven that a chitosan dermal substitute and chitosan skin substitute are suitable for wound healing in full-thickness wounds that are impaired due to radiation.
American Psychological Association (APA)
Mohd Hilmi, Abu Bakar& Halim, Ahmad Sukari& Jaafar, Hasnan& Asiah, Abu Bakar& Hassan, Asma’. 2013. Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030926
Modern Language Association (MLA)
Mohd Hilmi, Abu Bakar…[et al.]. Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1030926
American Medical Association (AMA)
Mohd Hilmi, Abu Bakar& Halim, Ahmad Sukari& Jaafar, Hasnan& Asiah, Abu Bakar& Hassan, Asma’. Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030926