Is Transforming Growth Factor-β Signaling Activated in Human Hypertrophied Prostate Treated by 5-Alpha Reductase Inhibitor?
Joint Authors
Chae, Han-Jung
Kim, Hye Kyung
Zhao, Chen
Choi, Bo Ram
Kim, Do Sung
Park, Jong Kwan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aim.
It is well known that androgen deprivation relates to penile fibrosis, so we hypothesize that long-term treatment with 5-alphareductase inhibitors (5ARIs) may increase the risk of fibrosis of prostate.
Patients and Methods.
Thirty-two BPH patients who underwent transurethral resection of the prostate were enrolled.
The patients were divided into two groups: group one, 16 patients underwent TURP who had been treated with tamsulosin for 2 years; group two, 16 patients underwent TURP who had been treated with combination of tamsulosin and dutasteride for at least 1 year.
We evaluated the expressions of nNOS, iNOS, eNOS, TGF-β1, TGF-β2, phosphorylated-Smad2/3 (p-Smad2/3), E-cadherin, N-cadherin, and α-smooth muscle actin in the resected prostate tissues by western blotting, and the TGF-β concentration was determined by ELISA kit.
Results.
The expressions of 3 isoforms of NOS were significantly increased in group 2 except of eNOS in lateral prostate, and the expressions of TGF-β1, TGF-β2, and p-Smad2/3 increased about 2-fold compared with group 1.
In group 2, the E-cadherin expression decreased while N-cadherin expression increased significantly.
Conclusions.
The overexpression of nNOS may contribute to prostate smooth muscle relaxation; however, long-time treatment with 5 ARI increases the risk of fibrosis of prostate.
American Psychological Association (APA)
Kim, Hye Kyung& Zhao, Chen& Choi, Bo Ram& Chae, Han-Jung& Kim, Do Sung& Park, Jong Kwan. 2013. Is Transforming Growth Factor-β Signaling Activated in Human Hypertrophied Prostate Treated by 5-Alpha Reductase Inhibitor?. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031226
Modern Language Association (MLA)
Kim, Hye Kyung…[et al.]. Is Transforming Growth Factor-β Signaling Activated in Human Hypertrophied Prostate Treated by 5-Alpha Reductase Inhibitor?. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031226
American Medical Association (AMA)
Kim, Hye Kyung& Zhao, Chen& Choi, Bo Ram& Chae, Han-Jung& Kim, Do Sung& Park, Jong Kwan. Is Transforming Growth Factor-β Signaling Activated in Human Hypertrophied Prostate Treated by 5-Alpha Reductase Inhibitor?. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031226