Potential therapeutic effects of guava leaves and chamomile flowers powder against liver toxicity in rats induced by carbon tetrachloride

Abstract EN

The present study aimed to investigate the potential therapeutic effect of different concentrations of guava leaves powder (GLP), chamomile flowers powder (CFP) and their mixture (Mix) against CCl4 - induced liver toxicity in rats.

Forty male albino rats weighting (150±10 g) were allocated in two main groups, the first group (n=5): Fed on basal diet and kept as a negative control group.

The second main group (hepatic rats): All rats (n=35) were injected by CCl4 to induce hepatotoxicity.

After induction, rats were allocated in 7 groups as following: Group 2: Fed on basal diet (positive control group).

Groups 3 and 4: Fed on basal diet +2 and 4% CFP, respectively.

Groups 5 and 6: Fed on basal diet +2 and 4% GLP, respectively.

Finally, groups 7 and 8: Fed on basal diet +2 and 4% Mix, respectively.

The experiment lasted for 28 days.

The results indicated that the best values were recorded in group eight (4% Mix) with percent of change 32.00 & 48.97 for ALT& AST, respectively, and 49.51, 47.63 and 59.40 for urea, uric acid, and creatine, respectively.

Therefore, this study recommended the combination of GLP and CFP to provide more effective results in the treatment of liver toxicity induced by carbon tetrachloride.