LPS-Induced Inflammation Potentiates the IL-1β-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants
Joint Authors
Dobek, Elżbieta
Herman, Anna
Herman, Andrzej Przemysław
Krawczyńska, Agata
Bochenek, Joanna
Tomaszewska-Zaremba, Dorota
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acting at the level of the brain, interleukin- (IL-)1β is considered to be one of the most potent downregulators of reproduction processes during immune/inflammatory challenge.
IL-1β suppresses gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus resulting in the inhibition of the luteinizing hormone (LH) release from the anterior pituitary (AP).
However, the presence of IL-1β receptors in the AP suggests the possible direct action of this cytokine on LH secretion.
The study was designed to determine the effect of IL-1β on the LH secretion from the AP explants collected from saline and LPS-treated ewes in the follicular phase.
It was found that IL-1β suppressed (P≤0.01) GnRH-stimulated LH release and LHβ gene expression in AP explants in both groups.
However, IL-1β action was more potent in the explants collected from LPS-treated animals.
Pituitaries from LPS-treated animals were characterized by increased (P≤0.01) IL-1 type I receptor and decreased (P≤0.01) GnRH receptor gene expression level compared to the saline-treated group.
IL-1β also affected the GnRH-R gene expression in explants collected from LPS-treated animals.
Our results show that direct action of IL-1β on the pituitary gonadotropes could be one of the reasons of the reproductive processes disorders accompanying an inflammatory state.
American Psychological Association (APA)
Herman, Andrzej Przemysław& Krawczyńska, Agata& Bochenek, Joanna& Dobek, Elżbieta& Herman, Anna& Tomaszewska-Zaremba, Dorota. 2013. LPS-Induced Inflammation Potentiates the IL-1β-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031292
Modern Language Association (MLA)
Herman, Andrzej Przemysław…[et al.]. LPS-Induced Inflammation Potentiates the IL-1β-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants. Journal of Immunology Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031292
American Medical Association (AMA)
Herman, Andrzej Przemysław& Krawczyńska, Agata& Bochenek, Joanna& Dobek, Elżbieta& Herman, Anna& Tomaszewska-Zaremba, Dorota. LPS-Induced Inflammation Potentiates the IL-1β-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031292