Lung Cancer Stem Cell Lose Their Stemness Default State after Exposure to Microgravity
Joint Authors
Coluccia, Pierpaolo
Pisanu, Maria Elena
Noto, Alessia
De Vitis, Claudia
Mancini, Rita
Giovagnoli, Maria Rosaria
Ricci, Alberto
Giarnieri, Enrico
Ciliberto, Gennaro
Cucina, Alessandra
Proietti, Sara
Masiello, Maria Grazia
Bizzarri, Mariano
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded.
Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity.
Our study provides evidence that a similar event occurs when cancer stem cells (CSCs) are cultured in microgravity.
In the same time, a significant increase in apoptosis was recorded: those data point out that microgravity rescues CSCs from their relative quiescent state, inducing CSCs to lose their stemness features, as documented by the decrease in ALDH and the downregulation of both Nanog and Oct-4 genes.
Those traits were stably acquired and preserved by CSCs when cells were placed again on a 1 g field.
Studies conducted in microgravity on CSCs may improve our understanding of the fundamental role exerted by biophysical forces in cancer cell growth and function.
American Psychological Association (APA)
Pisanu, Maria Elena& Noto, Alessia& De Vitis, Claudia& Masiello, Maria Grazia& Coluccia, Pierpaolo& Proietti, Sara…[et al.]. 2014. Lung Cancer Stem Cell Lose Their Stemness Default State after Exposure to Microgravity. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034470
Modern Language Association (MLA)
Pisanu, Maria Elena…[et al.]. Lung Cancer Stem Cell Lose Their Stemness Default State after Exposure to Microgravity. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034470
American Medical Association (AMA)
Pisanu, Maria Elena& Noto, Alessia& De Vitis, Claudia& Masiello, Maria Grazia& Coluccia, Pierpaolo& Proietti, Sara…[et al.]. Lung Cancer Stem Cell Lose Their Stemness Default State after Exposure to Microgravity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034470