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Contribution of α,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd.
Joint Authors
Bresolin, Tania M. B.
Wagner, Theodoro Marcel
Silva, Gislaine F.
Rocha, Lilian W.
Reichert, Simone
Claudino, Vanessa D.
Lucinda-Silva, Ruth M.
Meyre-Silva, Christiane
Cechinel Filho, Valdir
Machado, Marina da Silva
de Souza, Márcia Maria
Malheiros, Angela
Quintão, Nara L. M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of the study was to analyze the constituents of the dichloromethane fraction obtained from A.
moluccana and also to evaluate the anti-inflammatory and antinociceptive properties of α,β-amyrenone isolated from A.
moluccana in mice.
The dichloromethane fraction was evaluated by gas chromatography and submitted to purification.
The mixture of α,β-amyrenone was isolated and then evaluated using the carrageenan-induced paw-oedema or pleurisy and CFA-induced arthritis models in mice.
Five triterpenes, α,β-amyrenone, glutinol, and α,β-amyrin were isolated from dichloromethane fraction of A.
moluccana leaf extract.
The mixture of α,β-amyrenone, dosed orally, was able to reduce mechanical hypersensitivity and paw-oedema induced by carrageenan, interfering with neutrophil migration.
Similar results were observed in the carrageenan-induced pleurisy model.
Repeated administration of the compounds was also effective in reducing the mechanical sensitization and oedema developed in the arthritis model induced by CFA.
In conclusion, the results demonstrate that α,β-amyrenone interferes in both acute and chronic inflammatory processes.
We can infer that these effects involve, at least in part, a reduction in the neutrophil migration.
Therefore, it seems reasonable to suggest that α,β-amyrenone could represent a new therapeutic tool for the management of painful and inflammatory diseases, especially those presenting a chronic profile.
American Psychological Association (APA)
Quintão, Nara L. M.& Rocha, Lilian W.& Silva, Gislaine F.& Reichert, Simone& Claudino, Vanessa D.& Lucinda-Silva, Ruth M.…[et al.]. 2014. Contribution of α,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd.. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034519
Modern Language Association (MLA)
Quintão, Nara L. M.…[et al.]. Contribution of α,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd.. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034519
American Medical Association (AMA)
Quintão, Nara L. M.& Rocha, Lilian W.& Silva, Gislaine F.& Reichert, Simone& Claudino, Vanessa D.& Lucinda-Silva, Ruth M.…[et al.]. Contribution of α,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd.. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034519