Long-Term Effects and Prognosis in Acute Heart Failure Treated with Tolvaptan: The AVCMA Trial
Joint Authors
Nakazato, Kazuhiko
Yoshihisa, Akiomi
Abe, Yukihiko
Saito, Tomiyoshi
Ohwada, Takayuki
Suzuki, Hitoshi
Takeishi, Yasuchika
Saitoh, Shu-ichi
Sugimoto, Koichi
Suzuki, Satoshi
Kubota, Isao
Yamaki, Takayoshi
Kunii, Hiroyuki
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Diuresis is a major therapy for the reduction of congestive symptoms in acute decompensated heart failure (ADHF) patients.
We previously reported the efficacy and safety of tolvaptan compared to carperitide in hospitalized patients with ADHF.
There were some reports of cardio- and renal-protective effects in carperitide; therefore, the purpose of this study was to compare the long-term effects of tolvaptan and carperitide on cardiorenal function and prognosis.
Methods and Results.
One hundred and five ADHF patients treated with either tolvaptan or carperitide were followed after hospital discharge.
Levels of plasma B-type natriuretic peptide, serum sodium, potassium, creatinine, and estimated glomerular filtration rate were measured before administration of tolvaptan or carperitide at baseline, the time of discharge, and one year after discharge.
These data between tolvaptan and carperitide groups were not different one year after discharge.
Kaplan-Meier survival curves demonstrated that the event-free rate regarding all events, cardiac events, all cause deaths, and rehospitalization due to worsening heart failure was not significantly different between tolvaptan and carperitide groups.
Conclusions.
We demonstrated that tolvaptan had similar effects on cardiac and renal function and led to a similar prognosis in the long term, compared to carperitide.
American Psychological Association (APA)
Suzuki, Satoshi& Yoshihisa, Akiomi& Yamaki, Takayoshi& Sugimoto, Koichi& Kunii, Hiroyuki& Nakazato, Kazuhiko…[et al.]. 2014. Long-Term Effects and Prognosis in Acute Heart Failure Treated with Tolvaptan: The AVCMA Trial. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034545
Modern Language Association (MLA)
Suzuki, Satoshi…[et al.]. Long-Term Effects and Prognosis in Acute Heart Failure Treated with Tolvaptan: The AVCMA Trial. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034545
American Medical Association (AMA)
Suzuki, Satoshi& Yoshihisa, Akiomi& Yamaki, Takayoshi& Sugimoto, Koichi& Kunii, Hiroyuki& Nakazato, Kazuhiko…[et al.]. Long-Term Effects and Prognosis in Acute Heart Failure Treated with Tolvaptan: The AVCMA Trial. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034545