Niosomes of Ascorbic Acid and α-Tocopherol in the Cerebral Ischemia-Reperfusion Model in Male Rats
Joint Authors
Varshosaz, Jaleh
Taymouri, Somayeh
Pardakhty, Abbas
Asadi-Shekaari, Majid
Babaee, Abodolreza
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of the present study was to prepare a stable iv injectable formulation of ascorbic acid and α-tocopherol in preventing the cerebral ischemia.
Different niosomal formulations were prepared by Span and Tween mixed with cholesterol.
The physicochemical characteristics of niosomal formulations were evaluated in vitro.
For in vivo evaluation, the rats were made ischemic by middle cerebral artery occlusion model for 30 min and the selected formulation was used for determining its neuroprotective effect against cerebral ischemia.
Neuronal damage was evaluated by optical microscopy and transmission electron microscopy.
The encapsulation efficiency of ascorbic acid was increased to more than 84% by remote loading method.
The cholesterol content of the niosomes, the hydrophilicity potential of the encapsulated compounds, and the preparation method of niosomes were the main factors affecting the mean volume diameter of the prepared vesicles.
High physical stability of the niosomes prepared from Span 40 and Span 60 was demonstrated due to negligible size change of vesicles during 6 months storage at 4–8°C.
In vivo studies showed that ST60/Chol 35 : 35 : 30 niosomes had more neuroprotective effects against cerebral ischemic injuries in male rats than free ascorbic acid.
American Psychological Association (APA)
Varshosaz, Jaleh& Taymouri, Somayeh& Pardakhty, Abbas& Asadi-Shekaari, Majid& Babaee, Abodolreza. 2014. Niosomes of Ascorbic Acid and α-Tocopherol in the Cerebral Ischemia-Reperfusion Model in Male Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034574
Modern Language Association (MLA)
Varshosaz, Jaleh…[et al.]. Niosomes of Ascorbic Acid and α-Tocopherol in the Cerebral Ischemia-Reperfusion Model in Male Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034574
American Medical Association (AMA)
Varshosaz, Jaleh& Taymouri, Somayeh& Pardakhty, Abbas& Asadi-Shekaari, Majid& Babaee, Abodolreza. Niosomes of Ascorbic Acid and α-Tocopherol in the Cerebral Ischemia-Reperfusion Model in Male Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034574