Unaffected Arm Muscle Hypercatabolism in Dysphagic Subacute Stroke Patients: The Effects of Essential Amino Acid Supplementation
Joint Authors
Pasini, Evasio
Barbieri, Annalisa
Aquilani, Roberto
Verri, Manuela
Viglio, Simona
Iadarola, Paolo
Boselli, Mirella
Baiardi, Paola
Dossena, Maurizia
Bongiorno, Andria Innocenza
D’Antona, Giuseppe
Boschi, Federica
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Alterations in muscle protein turnover of the unaffected side of stroke patients could contribute to physical disability.
We investigated whether hypercatabolic activity occurred in unaffected arm muscle and whether supplemented essential amino acids (EAAs) could limit muscle hypercatabolism (MH).
Thirty-eight dysphagic subacute stroke subjects (<3 months after acute event) (29 males + 9 females; 69.7 ± 11.4 yrs) were enrolled and randomized to receive 8 g/day EAAs (n = 19; EAA group) or isocaloric placebo (maltodextrin; n = 19, Plac group).
Before randomization, all patients had their arterial (A) and venous (V) amino acids measured and muscle (A − V) differences calculated in the unaffected arm.
Eight matched and healthy subjects served as controls.
When compared to healthy controls, the entire stroke population showed significant muscle release (= negative value A − V) of the amino acid phenylalanine (phenyl-) indicating a prevalence of MH.
Moreover, randomized EAA and Plac groups had similar rates of MH.
After 38 days from the start of the protocol, the EAA group but not the Plac group had MH converted to balanced protein turnover or anabolic activity.
We concluded that muscle protein metabolism of the unaffected arm of dysphagic subacute stroke individuals could be characterized by MH which can be corrected by supplemented EAAs.
American Psychological Association (APA)
Aquilani, Roberto& Boselli, Mirella& D’Antona, Giuseppe& Baiardi, Paola& Boschi, Federica& Viglio, Simona…[et al.]. 2014. Unaffected Arm Muscle Hypercatabolism in Dysphagic Subacute Stroke Patients: The Effects of Essential Amino Acid Supplementation. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1034614
Modern Language Association (MLA)
Aquilani, Roberto…[et al.]. Unaffected Arm Muscle Hypercatabolism in Dysphagic Subacute Stroke Patients: The Effects of Essential Amino Acid Supplementation. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1034614
American Medical Association (AMA)
Aquilani, Roberto& Boselli, Mirella& D’Antona, Giuseppe& Baiardi, Paola& Boschi, Federica& Viglio, Simona…[et al.]. Unaffected Arm Muscle Hypercatabolism in Dysphagic Subacute Stroke Patients: The Effects of Essential Amino Acid Supplementation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1034614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034614