A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy
Joint Authors
Caretto, Amelia
Primerano, Liviana
Novara, Francesca
Genovese, Stefano
Rondinelli, Maurizio
Zuffardi, Orsetta
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Liddle’s syndrome (LS) is a rare heritable form of hypertension that often affects young patients.
It is caused by gain-of-function mutations of the kidney epithelial sodium channel (ENaC) and it is classically associated with hypokalemia and suppression of renin and aldosterone.
LS is characterized by responsiveness to ENaC inhibitors but not to mineralocorticoid receptor inhibitors.
Consequently the most effective treatment is amiloride.
This drug is not used in pregnancy, as it has not been sufficiently studied during gestation.
However for pregnant LS patient amiloride is the most effective drug in decreasing blood pressure.
Herein we report the case of a LS patient, who has been followed up by a multidisciplinary teamwork during her first pregnancy.
Hypertension worsened after the 25th week of gestation and amiloride was safely administered, firstly in combination with hydrochlorothiazide (the only formulation commercially available in Italy) and, thereafter, as a single drug.
Genetic testing was performed in the patient’s family in order to support diagnosis and clinical management.
American Psychological Association (APA)
Caretto, Amelia& Primerano, Liviana& Novara, Francesca& Zuffardi, Orsetta& Genovese, Stefano& Rondinelli, Maurizio. 2014. A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy. Case Reports in Obstetrics and Gynecology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034835
Modern Language Association (MLA)
Caretto, Amelia…[et al.]. A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy. Case Reports in Obstetrics and Gynecology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1034835
American Medical Association (AMA)
Caretto, Amelia& Primerano, Liviana& Novara, Francesca& Zuffardi, Orsetta& Genovese, Stefano& Rondinelli, Maurizio. A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy. Case Reports in Obstetrics and Gynecology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034835