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Goodpasture’s Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association
Joint Authors
Bahl, Amanjit
Das, Ashim
Gupta, Dheeraj
Garg, Mandeep
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Goodpasture’s syndrome is a rare clinical entity and is characterized by circulating autoantibodies which are principally directed against the glomerular/alveolar basement membrane.
The etiology of Goodpasture’s syndrome is still unknown.
Lung involvement occurs as a result of lung injury and the exposure of new epitopes to the immune system.
Recently, several studies have suggested the role of silica as one of etiological factors in ANCA associated vasculitis and glomerulonephritis.
Materials and Methods.
We present a case of a 40-year-old welder with silicosiderosis, who developed anti-GBM disease with p-ANCA positivity.
Case Report.
Patient presented to an emergency with gradually increasing breathlessness along with renal failure and died after short hospital stay.
Autopsy pathology findings revealed crescentic glomerulonephritis with linear glomerular basement membrane antibody deposition, splenic vasculitis, pulmonary haemorrhage, and pulmonary silicosiderosis.
Conclusion.
This case reinforces the role of environmental triggers like exposure to silica, metal dust, and tobacco in pathogenesis of Goodpasture’s syndrome and p-ANCA associated vasculitis.
American Psychological Association (APA)
Bahl, Amanjit& Das, Ashim& Gupta, Dheeraj& Garg, Mandeep. 2014. Goodpasture’s Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association. Case Reports in Pulmonology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034939
Modern Language Association (MLA)
Bahl, Amanjit…[et al.]. Goodpasture’s Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association. Case Reports in Pulmonology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034939
American Medical Association (AMA)
Bahl, Amanjit& Das, Ashim& Gupta, Dheeraj& Garg, Mandeep. Goodpasture’s Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association. Case Reports in Pulmonology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034939