Effect of Flos carthami Extract and α1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis
Joint Authors
Chen, Huey-Yi
Chen, Wen-Chi
Man, Kee-Ming
Wu, San-Yuan
Tsai, Kao-Sung
Lin, Yu-Ning
Chang, Chiao-Hui
Lee, Yuan-Ju
Shen, Jui-Lung
Tsai, Fuu-Jen
Winardi, Daniel
Hsieh, Wen-Tsong
Chen, Yung-Hsiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Traditional Chinese medicine (TCM) has been proposed to prevent urolithiasis.
In China, Flos carthami (FC, also known as Carthamus tinctorius) (Safflower; Chinese name: Hong Hua/紅花) has been used to treat urological diseases for centuries.
We previously performed a screening and confirmed the in vivo antilithic effect of FC extract.
Here, ex vivo organ bath experiment was further performed to study the effect of FC extract on the inhibition of phenylepinephrine (PE) (10−4 and 10−3 M) ureteral peristalsis of porcine ureters with several α1-adrenergic antagonists (doxazosin, tamsulosin, and terazosin) as experimental controls.
The results showed that doxazosin, tamsulosin, and terazosin dose (approximately 4.5 × 10−6 − 4.5 × 10−1 μg/mL) dependently inhibited both 10−4 and 10−3 M PE-induced ureteral peristalsis.
FC extract achieved 6.2% ± 10.1%, 21.8% ± 6.8%, and 24.0% ± 5.6% inhibitions of 10−4 M PE-induced peristalsis at doses of 5 × 103, 1 × 104, and 2 × 104 μg/mL, respectively, since FC extract was unable to completely inhibit PE-induced ureteral peristalsis, suggesting the antilithic effect of FC extract is related to mechanisms other than modulation of ureteral peristalsis.
American Psychological Association (APA)
Wu, San-Yuan& Man, Kee-Ming& Shen, Jui-Lung& Chen, Huey-Yi& Chang, Chiao-Hui& Tsai, Fuu-Jen…[et al.]. 2014. Effect of Flos carthami Extract and α1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035198
Modern Language Association (MLA)
Wu, San-Yuan…[et al.]. Effect of Flos carthami Extract and α1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035198
American Medical Association (AMA)
Wu, San-Yuan& Man, Kee-Ming& Shen, Jui-Lung& Chen, Huey-Yi& Chang, Chiao-Hui& Tsai, Fuu-Jen…[et al.]. Effect of Flos carthami Extract and α1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035198