St. John’s Wort Has Metabolically Favorable Effects on Adipocytes In Vivo
Joint Authors
Stephens, Jacqueline M.
Fuller, Scott
Beyl, Robbie
Mynatt, Randall
Richard, Allison J.
Ribnicky, David M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In addition to serving as a storage site for reserve energy, adipocytes play a critical role in whole-body insulin sensitivity and glucose metabolism.
St.
John’s Wort (SJW) is a botanical supplement widely used as an over-the-counter treatment of depression and a variety of other conditions associated with anxiety and nerve pain.
Previous studies in our laboratory demonstrated that SJW inhibits insulin-stimulated glucose uptake and adipocyte differentiation in cultured murine and mature human adipocytes.
To investigate the effects of SJW on adipocyte function in vivo, we utilized C57BL/6J mice.
In our studies, mice were administered SJW extract (200 mg/kg) once daily by gavage for two weeks.
In contrast to our in vitro studies, mice treated with SJW extract showed increased levels of adiponectin in white adipose tissue in a depot specific manner (P<0.01).
SJW also exerted an insulin-sensitizing effect as indicated by a significant increase in insulin-stimulated Akt serine phosphorylation in epididymal white adipose tissue (P<0.01).
Food intake, body weight, fasting blood glucose, and fasting insulin did not differ between the two groups.
These results are important as they indicate that SJW does not promote metabolic dysfunction in adipose tissue in vivo.
American Psychological Association (APA)
Fuller, Scott& Richard, Allison J.& Ribnicky, David M.& Beyl, Robbie& Mynatt, Randall& Stephens, Jacqueline M.. 2014. St. John’s Wort Has Metabolically Favorable Effects on Adipocytes In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035429
Modern Language Association (MLA)
Fuller, Scott…[et al.]. St. John’s Wort Has Metabolically Favorable Effects on Adipocytes In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035429
American Medical Association (AMA)
Fuller, Scott& Richard, Allison J.& Ribnicky, David M.& Beyl, Robbie& Mynatt, Randall& Stephens, Jacqueline M.. St. John’s Wort Has Metabolically Favorable Effects on Adipocytes In Vivo. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035429