Evaluation of the In Vitro Antiplasmodial, Antileishmanial, and Antitrypanosomal Activity of Medicinal Plants Used in Saudi and Yemeni Traditional Medicine
Joint Authors
Cos, Paul
Mothana, R. A. A.
Al-Ajmi, Mohamed F.
Maes, Louis
al-Musayeib, Nawal
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The antiplasmodial, antileishmanial, and antitrypanosomal activity of twenty-five medicinal plants distributed in Saudi Arabia and Yemen was evaluated.
The plants were extracted with methanol and screened in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi, and free trypomastigotes of T.
brucei.
To assess selectivity, cytotoxicity was determined on MRC-5 cells.
Criteria for activity were an IC50<10 μg/mL and high selectivity (SI).
Seven plants showed interesting antiprotozoal activity in one or more models.
Extracts of Caralluma penicillata and Acalypha ciliata showed fairly good activity against P.
falciparum with IC50 of 6.7 and 10.8 μg/mL and adequate selectivity (SI>9.6 and >5.9).
Interesting activity against L.
infantum was obtained with Verbascum bottae (IC50 of 3.2 μg/mL, SI 10.2) and Solanum glabratum (IC50 8.1 μg/mL, SI 3.4).
The extracts of C.
penicillata, Leucas virgata, Loranthus regularis, and V.
bottae exhibited moderate activity against T.
brucei (IC50 8.5, 8.1, 8.3, and 2.3 μg/mL; SI>7.6, 7.7, 4.3, and >14.1).
These results partly support the traditional use of some of the selected medicinal plants and warrant further investigations into the putative active constituents.
American Psychological Association (APA)
Mothana, R. A. A.& al-Musayeib, Nawal& Al-Ajmi, Mohamed F.& Cos, Paul& Maes, Louis. 2014. Evaluation of the In Vitro Antiplasmodial, Antileishmanial, and Antitrypanosomal Activity of Medicinal Plants Used in Saudi and Yemeni Traditional Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035445
Modern Language Association (MLA)
Mothana, R. A. A.…[et al.]. Evaluation of the In Vitro Antiplasmodial, Antileishmanial, and Antitrypanosomal Activity of Medicinal Plants Used in Saudi and Yemeni Traditional Medicine. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035445
American Medical Association (AMA)
Mothana, R. A. A.& al-Musayeib, Nawal& Al-Ajmi, Mohamed F.& Cos, Paul& Maes, Louis. Evaluation of the In Vitro Antiplasmodial, Antileishmanial, and Antitrypanosomal Activity of Medicinal Plants Used in Saudi and Yemeni Traditional Medicine. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035445