Amoebicidal Activity of Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants in an Amoebic Liver Abscess Hamster Model
Joint Authors
Rodríguez, Martín Gerardo
Ávila-Blanco, Manuel Enrique
Moreno Duque, José Luis
Muñoz-Ortega, Martin
Ventura-Juárez, Javier
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Amebiasis is a parasitic disease that extends worldwide and is a public health problem in developing countries.
Metronidazole is the drug recommended in the treatment of amebiasis, but its contralateral effects and lack of continuity of treatment induce low efficiency, coupled with the appearance of resistant amoebic strains.
Therefore, the search of new compounds with amoebicidal activity is urgent and important.
In this study, we evaluated the in vitro and in vivo antiamoebic activity of the essential oil Dysphania ambrosioides (L.) Mosyakin & Clemants.
It exhibited an IC50 = 0.7 mg/mL against trophozoites.
The oral administration of essential oil (8 mg/kg and 80 mg/kg) to hamster infected with Entamoeba histolytica reverted the infection.
Ascaridole was identified as the main component of essential oil of D.
ambrosioides.
The identification of amoebicidal activity of Ascaridole gives support to the traditional use.
Further studies with Ascaridole will be carried out to understand the mechanism involved.
American Psychological Association (APA)
Ávila-Blanco, Manuel Enrique& Rodríguez, Martín Gerardo& Moreno Duque, José Luis& Muñoz-Ortega, Martin& Ventura-Juárez, Javier. 2014. Amoebicidal Activity of Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants in an Amoebic Liver Abscess Hamster Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035463
Modern Language Association (MLA)
Ávila-Blanco, Manuel Enrique…[et al.]. Amoebicidal Activity of Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants in an Amoebic Liver Abscess Hamster Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035463
American Medical Association (AMA)
Ávila-Blanco, Manuel Enrique& Rodríguez, Martín Gerardo& Moreno Duque, José Luis& Muñoz-Ortega, Martin& Ventura-Juárez, Javier. Amoebicidal Activity of Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants in an Amoebic Liver Abscess Hamster Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035463