ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level
Joint Authors
Cheng, Xiaoyun
Song, Kexiu
Han, Yingchun
Zhang, Linhua
Liu, Guoqing
Yang, Peng
Bu, Le
Sheng, Hui
Qu, Shen
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions.
SR-BI mediates the selective uptake of HDL-C.
SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved.
Ectopic ATP synthase β-chain in hepatocytes has been previously characterized as an apoA-I receptor, triggering HDL internalization.
This study was undertaken to identify the overexpression of ectopic ATP synthase β-chain on DIL-HDL uptake in primary hepatocytes in vitro and on plasma HDL levels in SR-BI knockout mice.
Human ATP synthase β-chain cDNA was delivered to the mouse liver by adenovirus and GFP adenovirus as control.
The adenovirus-mediated overexpression of β-chain was identified at both mRNA and protein levels on mice liver and validated by its increasing of DiL-HDL uptake in primary hepatocytes.
In response to hepatic overexpression of β-chain, plasma HDL-C levels and cholesterol were reduced in SR-BI knockout mice, compared with the control.
The present data suggest that ATP synthase β-chain can serve as the endocytic receptor of HDL, and its overexpression can reduce plasma HDL-C.
American Psychological Association (APA)
Song, Kexiu& Han, Yingchun& Zhang, Linhua& Liu, Guoqing& Yang, Peng& Cheng, Xiaoyun…[et al.]. 2014. ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036477
Modern Language Association (MLA)
Song, Kexiu…[et al.]. ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level. International Journal of Endocrinology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1036477
American Medical Association (AMA)
Song, Kexiu& Han, Yingchun& Zhang, Linhua& Liu, Guoqing& Yang, Peng& Cheng, Xiaoyun…[et al.]. ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036477