Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years
Joint Authors
Lips, Paul
Haider, Ahmad
Meergans, Ulrich
Traish, Abdulmaged
Saad, Farid
Doros, Gheorghe
Gooren, Louis J.
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Testosterone deficiency leads to bone loss and testosterone treatment has a beneficial effect.
This study investigated the effects of normalizing serum testosterone on bone mineral density in 45 men with osteoporosis, diagnosed with testosterone deficiency (serum testosterone levels <12.1 nmol/L, T-scores: (mean ± SD) −3.12 ± 0.45, minimum: −4.10, and maximum: −2.60).
In a cumulative, prospective, registry study of hypogonadal men (mean age: 53 ± 7 years) they received parenteral testosterone undecanoate of 1000 mg/12 weeks for up to six years.
After one year 44 men were included in the registry, after two years 36 men, after three years 32 men, after four years 25 men, after five years 10 men and after six years 4 men.
The declining numbers do not reflect drop-out rates but are a result of the registry design.
Over the 6 year period there was a significant and progressive improvement of the T-scores in these men.
Normalizing of serum testosterone leads to an improvement of bone mineral density and this improvement was progressive with the time period of testosterone administration.
In this study of 6-years many men with testosterone deficiency suffered from classical diagnoses (Klinefelter’s syndrome and testicular pathology) hitherto undiagnosed.
American Psychological Association (APA)
Haider, Ahmad& Meergans, Ulrich& Traish, Abdulmaged& Saad, Farid& Doros, Gheorghe& Lips, Paul…[et al.]. 2014. Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036505
Modern Language Association (MLA)
Haider, Ahmad…[et al.]. Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036505
American Medical Association (AMA)
Haider, Ahmad& Meergans, Ulrich& Traish, Abdulmaged& Saad, Farid& Doros, Gheorghe& Lips, Paul…[et al.]. Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036505