Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis
Joint Authors
Arellano-Rodríguez, Mariela
Torres-Del-Muro, Felipe de Jesús
Daza-Benítez, Leonel
Bollain-y-Goytia, Juan José
Herrera-Esparza, Rafael
Muñoz-Valle, José Francisco
Avalos-Díaz, Esperanza
Source
International Journal of Nephrology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study was performed to clarify the role of soluble Fas (sFas) in lupus nephritis (LN) and establish a potential relationship between LN and the −670 polymorphism of Fas in 67 patients with systemic lupus erythematosus (SLE), including a subset of 24 LN patients with proteinuria.
Additionally, a group of 54 healthy subjects (HS) was included.
The allelic frequency of the −670 polymorphism of Fas was determined using PCR-RFLP analysis, and sFas levels were assessed by ELISA.
Additionally, the WT-1 protein level in urine was measured.
The Fas receptor was determined in biopsies by immunohistochemistry (IHC) and in situ hybridization (FISH) and apoptotic features by TUNEL.
Results.
The −670 Fas polymorphism showed that the G allele was associated with increased SLE susceptibility, with an odds ratio (OR) of 1.86.
The sFas was significantly higher in LN patients with the G/G genotype, and this subgroup exhibited correlations between the sFas level and proteinuria and increased urinary WT-1 levels.
LN group shows increased expression of Fas and apoptotic features.
In conclusion, our results indicate that the G allele of the −670 polymorphism of Fas is associated with genetic susceptibility in SLE patients with elevated levels of sFas in LN with proteinuria.
American Psychological Association (APA)
Bollain-y-Goytia, Juan José& Arellano-Rodríguez, Mariela& Torres-Del-Muro, Felipe de Jesús& Daza-Benítez, Leonel& Muñoz-Valle, José Francisco& Avalos-Díaz, Esperanza…[et al.]. 2014. Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036754
Modern Language Association (MLA)
Bollain-y-Goytia, Juan José…[et al.]. Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis. International Journal of Nephrology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036754
American Medical Association (AMA)
Bollain-y-Goytia, Juan José& Arellano-Rodríguez, Mariela& Torres-Del-Muro, Felipe de Jesús& Daza-Benítez, Leonel& Muñoz-Valle, José Francisco& Avalos-Díaz, Esperanza…[et al.]. Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036754