Potential Use of C602-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer
Joint Authors
Uekama, Kaneto
Altaf, Abdulmalik
Aldawsari, Hibah
Banjar, Zainy M.
Iohara, Daisuke
Anraku, Makoto
Hirayama, Fumitoshi
Source
International Journal of Photoenergy
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The photosensitizing ability of C60/2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) nanoparticles under visible light irradiation was studied by electron spin resonance (ESR) and phototoxicity on cancer cells.
In addition, the photoinduced antitumor effect to the tumor-bearing mice was evaluated.
C60 nanoparticles were prepared by grinding a mixture of HP-β-CyD.
The resulting C60/HP-β-CyD nanoparticles were highly-sensitive to visible light and generated higher levels of 1O2 than protoporphyrin IX (PpIX).
C60/HP-β-CyD reduced the viability of cancer cells (HeLa cells and A549 cells) in response to irradiation by visible light in a dose-dependent manner.
The IC50 values of the C60/HP-β-CyD nanoparticles was 10 μM for HeLa cells and 60 μM for A549 cells at an irradiation level of 35 mW/cm2.
The photodynamic effect of C60/HP-β-CyD nanoparticles on the in vivo growth of mouse sarcoma S-180 cells was evaluated after intratumor injection.
The outcome of PDT by C60/HP-β-CyD was directly dependent on the dose of irradiated light.
Treatment with C60/HP-β-CyD nanoparticles at a C60 dose of 2.0 mg/kg under visible light irradiation at 350 mW/cm2 (63 J/cm2) markedly suppressed tumor growth, whereas that at 30 J/cm2 was less effective.
These findings suggest that C60/HP-β-CyD nanoparticles represent a promising candidate for use in cancer treatment by PDT.
American Psychological Association (APA)
Altaf, Abdulmalik& Aldawsari, Hibah& Banjar, Zainy M.& Iohara, Daisuke& Anraku, Makoto& Uekama, Kaneto…[et al.]. 2014. Potential Use of C602-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer. International Journal of Photoenergy،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1037183
Modern Language Association (MLA)
Altaf, Abdulmalik…[et al.]. Potential Use of C602-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer. International Journal of Photoenergy No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1037183
American Medical Association (AMA)
Altaf, Abdulmalik& Aldawsari, Hibah& Banjar, Zainy M.& Iohara, Daisuke& Anraku, Makoto& Uekama, Kaneto…[et al.]. Potential Use of C602-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer. International Journal of Photoenergy. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1037183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037183