Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light
Joint Authors
Kushibiki, Toshihiro
Okawa, Shinpei
Hirasawa, Takeshi
Ishihara, Miya
Source
International Journal of Photoenergy
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In optogenetics, targeted illumination is used to control the functions of cells expressing exogenous light-activated proteins.
Adoption of the optogenetic methods has expanded rapidly in recent years.
In this review, we describe the photosensitive channel proteins involved in these methods, describe techniques for their targeting to neurons and other cell types both within and outside the nervous system, and discuss their applications in the field of neuroscience and beyond.
We focus especially on the channelrhodopsin protein ChR2, the photosensitive protein most commonly employed in optogenetics.
ChR2 has been used by many groups to control neuronal activity, both in vitro and in vivo, on short time scales and with exquisite anatomical precision.
In addition, we describe more recently developed tools such as opsin/G protein-coupled receptor chimeric molecules and a light-activated transgene system.
In addition, we discuss the potential significance of optogenetics in the development of clinical therapeutics.
Although less than a decade old, optogenetics is already responsible for enormous progress in disparate fields, and its future is unquestionably bright.
American Psychological Association (APA)
Kushibiki, Toshihiro& Okawa, Shinpei& Hirasawa, Takeshi& Ishihara, Miya. 2014. Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light. International Journal of Photoenergy،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1037398
Modern Language Association (MLA)
Kushibiki, Toshihiro…[et al.]. Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light. International Journal of Photoenergy No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1037398
American Medical Association (AMA)
Kushibiki, Toshihiro& Okawa, Shinpei& Hirasawa, Takeshi& Ishihara, Miya. Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light. International Journal of Photoenergy. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1037398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037398