Synthesis, Single Crystal X-Ray Structure, and Antimicrobial Activity of 6-(1,3-Benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one
Joint Authors
Ghabbour, Hazem A.
Attia, Mohamed I.
El-Brollosy, Nasser R.
Kansoh, Amany L.
Al-Wabli, Reem I.
Fun, Hoong-Kun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Synthesis, X-ray structure and antimicrobial activity of 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one (8) are reported.
Compound 8 exhibited activity towards S.
aureus with MIC value of 0.0619 μmol/mL while it showed activity towards B.
subtilis, B.
cereus, C.
albicans, and A.
niger with MIC = 0.1859 μmol/mL.
Single crystal X-ray structure of the title compound 8 confirmed its S-alkylation.
The title compound crystallizes in the triclinic, P -1, a = 11.1220 (5) Å, b = 12.2241 (5) Å, c = 21.5246 (9) Å, α = 88.958 (2)°, β = 79.836 (2)°, γ = 79.384 (2)°, V = 2830.9 (2) Å3, Z = 6 , R ( F ) = 0.046 , w R ( F 2 ) = 0.110 , T = 100 K.
The crystal structure is stabilized by weak intermolecular C–H ⋯ O and N–H ⋯ O hydrogen interactions.
American Psychological Association (APA)
Attia, Mohamed I.& El-Brollosy, Nasser R.& Kansoh, Amany L.& Ghabbour, Hazem A.& Al-Wabli, Reem I.& Fun, Hoong-Kun. 2014. Synthesis, Single Crystal X-Ray Structure, and Antimicrobial Activity of 6-(1,3-Benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1039990
Modern Language Association (MLA)
Attia, Mohamed I.…[et al.]. Synthesis, Single Crystal X-Ray Structure, and Antimicrobial Activity of 6-(1,3-Benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one. Journal of Chemistry No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1039990
American Medical Association (AMA)
Attia, Mohamed I.& El-Brollosy, Nasser R.& Kansoh, Amany L.& Ghabbour, Hazem A.& Al-Wabli, Reem I.& Fun, Hoong-Kun. Synthesis, Single Crystal X-Ray Structure, and Antimicrobial Activity of 6-(1,3-Benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1039990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1039990