Impaired β Cell Function in Chinese Newly Diagnosed Type 2 Diabetes Mellitus with Hyperlipidemia
Joint Authors
Ma, Yuhang
Wang, Yufan
Huang, Qianfang
Ren, Qian
Chen, Su
Zhang, Aifang
Zhao, Li
Zhen, Qin
Peng, Yongde
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The objective is to explore the effects of hyperlipidemia on β cell function in newly diagnosed type 2 diabetes mellitus (T2DM).
208 patients were enrolled in the study and were divided into newly diagnosed T2DM with hyperlipidemia (132 patients) and without hyperlipidemia (76 patients).
Demographic data, glucose levels, insulin levels, lipid profiles, homeostasis model assessment for β cell function index (HOMA-β), homeostasis model assessment for insulin resistance index (HOMA-IR), and quantitative insulin-sensitivity check index (QUICKI) were compared between the two groups.
We found that comparing with those of normal lipid levels, the subjects of newly diagnosed T2DM with hyperlipidemia were younger, and had declined HOMA-β.
However, the levels of HOMA-β were comparable regardless of different lipid profiles (combined hyperlipidemia, hypertriglyceridemia, and hypercholesterolemia).
Multiple stepwise linear regression analysis showed that high fasting plasma glucose (FPG), decreased fasting insulin level (FINS), and high triglyceride (TG) were independent risk factors of β cell dysfunction in newly diagnosed T2DM.
Therefore, the management of dyslipidemia, together with glucose control, may be beneficial for T2DM with hyperlipidemia.
American Psychological Association (APA)
Ma, Yuhang& Wang, Yufan& Huang, Qianfang& Ren, Qian& Chen, Su& Zhang, Aifang…[et al.]. 2014. Impaired β Cell Function in Chinese Newly Diagnosed Type 2 Diabetes Mellitus with Hyperlipidemia. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040303
Modern Language Association (MLA)
Ma, Yuhang…[et al.]. Impaired β Cell Function in Chinese Newly Diagnosed Type 2 Diabetes Mellitus with Hyperlipidemia. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040303
American Medical Association (AMA)
Ma, Yuhang& Wang, Yufan& Huang, Qianfang& Ren, Qian& Chen, Su& Zhang, Aifang…[et al.]. Impaired β Cell Function in Chinese Newly Diagnosed Type 2 Diabetes Mellitus with Hyperlipidemia. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040303