Ketosis Onset Type 2 Diabetes Had Better Islet β -Cell Function and More Serious Insulin Resistance
Joint Authors
Sun, Liao
Zou, Lingling
Lu, Hongyun
Hu, Fang
Zeng, Yingjuan
Luo, Shunkui
Sun, Ying
Liu, Hong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diabetic ketosis had been identified as a characteristic of type 1 diabetes mellitus (T1DM), but now emerging evidence has identified that they were diagnosed as T2DM after long time follow up.
This case control study was aimed at comparing the clinical characteristic, β -cell function, and insulin resistance of ketosis and nonketotic onset T2DM and providing evidence for treatment selection.
140 cases of newly diagnosed T2DM patients were divided into ketosis (62 cases) and nonketotic onset group (78 cases).
After correction of hyperglycemia and ketosis with insulin therapy, plasma C-peptide concentrations were measured at 0, 0.5, 1, 2, and 3 hours after 75 g glucose oral administration.
Area under the curve (AUC) of C-peptide was calculated.
Homoeostasis model assessment was used to estimate basal β -cell function (HOMA- β ) and insulin resistance (HOMA-IR).
Our results showed that ketosis onset group had higher prevalence of nonalcoholic fatty liver disease (NAFLD) than nonketotic group ( P = 0.04 ).
Ketosis onset group had increased plasma C-peptide levels at 0 h, 0.5 h, and 3 h and higher AUC 0 – 0.5 , AUC 0 – 1 , AUC 0 – 3 ( P < 0.05 ).
Moreover, this group also had higher HOMA- β and HOMA-IR than nonketotic group ( P < 0.05 ).
From these data, we concluded that ketosis onset T2DM had better islet β -cell function and more serious insulin resistance than nonketotic onset T2DM.
American Psychological Association (APA)
Lu, Hongyun& Hu, Fang& Zeng, Yingjuan& Zou, Lingling& Luo, Shunkui& Sun, Ying…[et al.]. 2014. Ketosis Onset Type 2 Diabetes Had Better Islet β -Cell Function and More Serious Insulin Resistance. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040305
Modern Language Association (MLA)
Lu, Hongyun…[et al.]. Ketosis Onset Type 2 Diabetes Had Better Islet β -Cell Function and More Serious Insulin Resistance. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040305
American Medical Association (AMA)
Lu, Hongyun& Hu, Fang& Zeng, Yingjuan& Zou, Lingling& Luo, Shunkui& Sun, Ying…[et al.]. Ketosis Onset Type 2 Diabetes Had Better Islet β -Cell Function and More Serious Insulin Resistance. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040305