Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly
Joint Authors
Yamada, Eriko
Takeuchi, Mika
Kurata, Miki
Kazumi, Tsutomu
Fukuo, Keisuke
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension.
Methods.
Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of whom had hypertension.
Results.
Systolic blood pressure (standardized β, 0.775), log tumor necrosis factor-α (TNF-α, standardized β, 0.110), age (standardized β, 0.140), and neutrophil count (standardized β, 0.114) emerged as determinants of PP independent of high-sensitivity C-reactive protein, interleukin-6, monocyte count, plasminogen activator inhibitor-1, homeostasis model assessment of insulin resistance, HDL-cholesterol, and adiponectin (R2 = 0.772).
Conclusions.
The present studies have demonstrated an independent association of higher PP with higher TNF-α, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension.
American Psychological Association (APA)
Yamada, Eriko& Takeuchi, Mika& Kurata, Miki& Kazumi, Tsutomu& Fukuo, Keisuke. 2014. Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040404
Modern Language Association (MLA)
Yamada, Eriko…[et al.]. Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly. Journal of Diabetes Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040404
American Medical Association (AMA)
Yamada, Eriko& Takeuchi, Mika& Kurata, Miki& Kazumi, Tsutomu& Fukuo, Keisuke. Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040404