Chronic Inflammation and Cytokines in the Tumor Microenvironment
Joint Authors
Hermoso, Marcela A.
Landskron, Glauben
De la Fuente, Marjorie
Thuwajit, Peti
Thuwajit, Chanitra
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue.
However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis.
Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer.
In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis.
Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma.
American Psychological Association (APA)
Landskron, Glauben& De la Fuente, Marjorie& Thuwajit, Peti& Thuwajit, Chanitra& Hermoso, Marcela A.. 2014. Chronic Inflammation and Cytokines in the Tumor Microenvironment. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-1040771
Modern Language Association (MLA)
Landskron, Glauben…[et al.]. Chronic Inflammation and Cytokines in the Tumor Microenvironment. Journal of Immunology Research No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-1040771
American Medical Association (AMA)
Landskron, Glauben& De la Fuente, Marjorie& Thuwajit, Peti& Thuwajit, Chanitra& Hermoso, Marcela A.. Chronic Inflammation and Cytokines in the Tumor Microenvironment. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-1040771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040771